djabberdjaw is an alpha-quality Jabber bot written in Python that uses Django as an administrative interface to manage bot and user profiles. I've included a couple of plugins out of the box that will allow you to perform queries against Z39.50 targets and OCLC's xISBN API (assuming you have the requisite modules). djabberdjaw requires Django 1.0 or later, jabberbot, and xmpppy. It's available either from PyPI (including using easy_install) or via Subversion. You can browse the Subversion repository, too.
